Ontology highlight
ABSTRACT:
SUBMITTER: Hart EM
PROVIDER: S-EPMC7414184 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Hart Elizabeth M EM Gupta Meera M Wühr Martin M Silhavy Thomas J TJ
Proceedings of the National Academy of Sciences of the United States of America 20200716 31
The outer membrane (OM) of gram-negative bacteria confers innate resistance to toxins and antibiotics. Integral β-barrel outer membrane proteins (OMPs) function to establish and maintain the selective permeability of the OM. OMPs are assembled into the OM by the β-barrel assembly machine (BAM), which is composed of one OMP-BamA-and four lipoproteins-BamB, C, D, and E. BamB, C, and E can be removed individually with only minor effects on barrier function; however, depletion of either BamA or BamD ...[more]