Immunoproteasome in IgA Nephropathy: State-of-Art and Future Perspectives.
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ABSTRACT:
SUBMITTER: Gan T
PROVIDER: S-EPMC7415421 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Immunoproteasome in IgA Nephropathy: State-of-Art and Future Perspectives.
Gan Ting T Li Yang Y Zhou Xu-Jie XJ Zhang Hong H
International journal of biological sciences 20200719 14
IgA nephropathy (IgAN) is a leading cause of chronic kidney disease and renal failure. The exact pathogenesis of IgAN is not well defined, but some genetic studies have led to a novel discovery that the immunoproteasome probably plays an important role in IgAN. The immunoproteasome is a proteasome variant that is expressed when cells are stressed or receive inflammatory signals. While immunoproteasome is suggested to be mainly involved in major histocompatibility complex-I (MHC-I) antigen presen ...[more]
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