Unknown

Dataset Information

0

Immune Response and COVID-19: A mirror image of Sepsis.


ABSTRACT: The emergence of SARS-CoV-2 virus and its associated disease COVID-19 have triggered significant threats to public health, in addition to political and social changes. An important number of studies have reported the onset of symptoms compatible with pneumonia accompanied by coagulopathy and lymphocytopenia during COVID-19. Increased cytokine levels, the emergence of acute phase reactants, platelet activation and immune checkpoint expression are some of the biomarkers postulated in this context. As previously observed in prolonged sepsis, T-cell exhaustion due to SARS-CoV-2 and even their reduction in numbers due to apoptosis hinder the response to the infection. In this review, we synthesized the immune changes observed during COVID-19, the role of immune molecules as severity markers for patient stratification and their associated therapeutic options.

SUBMITTER: Lopez-Collazo E 

PROVIDER: S-EPMC7415424 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

altmetric image

Publications

Immune Response and COVID-19: A mirror image of Sepsis.

López-Collazo Eduardo E   Avendaño-Ortiz José J   Martín-Quirós Alejandro A   Aguirre Luis A LA  

International journal of biological sciences 20200709 14


The emergence of SARS-CoV-2 virus and its associated disease COVID-19 have triggered significant threats to public health, in addition to political and social changes. An important number of studies have reported the onset of symptoms compatible with pneumonia accompanied by coagulopathy and lymphocytopenia during COVID-19. Increased cytokine levels, the emergence of acute phase reactants, platelet activation and immune checkpoint expression are some of the biomarkers postulated in this context.  ...[more]

Similar Datasets

2023-03-24 | GSE222393 | GEO
2022-11-29 | GSE199816 | GEO
2021-03-17 | E-MTAB-10026 | biostudies-arrayexpress
| S-EPMC7703472 | biostudies-literature
| S-EPMC9833533 | biostudies-literature
| S-EPMC4201793 | biostudies-other
| S-EPMC8932087 | biostudies-literature
| PRJNA921862 | ENA
| S-EPMC10045101 | biostudies-literature
| S-EPMC7217020 | biostudies-literature