Proteins from SARS-CoV-2 reduce T cell proliferation: A mirror image of sepsis.
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ABSTRACT:
SUBMITTER: Avendano-Ortiz J
PROVIDER: S-EPMC7703472 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Publications
Proteins from SARS-CoV-2 reduce T cell proliferation: A mirror image of sepsis.
Avendaño-Ortiz José J Lozano-Rodríguez Roberto R Martín-Quirós Alejandro A Maroun-Eid Charbel C Terrón Verónica V Valentín Jaime J Montalbán-Hernández Karla K Ruiz de la Bastida Fátima F García-Garrido Miguel A MA Cubillos-Zapata Carolina C Del Balzo-Castillo Álvaro Á Aguirre Luis A LA López-Collazo Eduardo E
Heliyon 20201130 12
Increased cytokine levels, acute phase reactants and immune checkpoint expression changes have been described in patients with Coronavirus Disease 2019 (COVID-19). Here, we have reported a monocyte polarization towards a low HLA-DR and high PD-L1 expression after long exposure to proteins from SARS-CoV-2. Moreover, CD86 expression was also reduced over SARS-CoV-2 proteins exposure. Additionally, T-cells proliferation was significantly reduced after stimulation with these proteins. Eventually, pa ...[more]
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