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Proteins from SARS-CoV-2 reduce T cell proliferation: A mirror image of sepsis.


ABSTRACT: Increased cytokine levels, acute phase reactants and immune checkpoint expression changes have been described in patients with Coronavirus Disease 2019 (COVID-19). Here, we have reported a monocyte polarization towards a low HLA-DR and high PD-L1 expression after long exposure to proteins from SARS-CoV-2. Moreover, CD86 expression was also reduced over SARS-CoV-2 proteins exposure. Additionally, T-cells proliferation was significantly reduced after stimulation with these proteins. Eventually, patients with long-term SARS-CoV-2 infection also exhibited a significant blockade of T-cells proliferation.

SUBMITTER: Avendano-Ortiz J 

PROVIDER: S-EPMC7703472 | biostudies-literature |

REPOSITORIES: biostudies-literature

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