Ontology highlight
ABSTRACT:
SUBMITTER: Veneziano R
PROVIDER: S-EPMC7415668 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Veneziano Rémi R Moyer Tyson J TJ Stone Matthew B MB Wamhoff Eike-Christian EC Read Benjamin J BJ Mukherjee Sayak S Shepherd Tyson R TR Das Jayajit J Schief William R WR Irvine Darrell J DJ Bathe Mark M
Nature nanotechnology 20200629 8
Vaccine efficacy can be increased by arraying immunogens in multivalent form on virus-like nanoparticles to enhance B-cell activation. However, the effects of antigen copy number, spacing and affinity, as well as the dimensionality and rigidity of scaffold presentation on B-cell activation remain poorly understood. Here, we display the clinical vaccine immunogen eOD-GT8, an engineered outer domain of the HIV-1 glycoprotein-120, on DNA origami nanoparticles to systematically interrogate the impac ...[more]