Ontology highlight
ABSTRACT:
SUBMITTER: Sherman E
PROVIDER: S-EPMC3225724 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Sherman Eilon E Barr Valarie V Manley Suliana S Patterson George G Balagopalan Lakshmi L Akpan Itoro I Regan Carole K CK Merrill Robert K RK Sommers Connie L CL Lippincott-Schwartz Jennifer J Samelson Lawrence E LE
Immunity 20111104 5
Receptor-regulated cellular signaling often is mediated by formation of transient, heterogeneous protein complexes of undefined structure. We used single and two-color photoactivated localization microscopy to study complexes downstream of the T cell antigen receptor (TCR) in single-molecule detail at the plasma membrane of intact T cells. The kinase ZAP-70 distributed completely with the TCRζ chain and both partially mixed with the adaptor LAT in activated cells, thus showing localized activati ...[more]