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Rapid SERS Detection of Thiol-Containing Natural Products in Culturing Complex.

ABSTRACT: Thiol-containing natural products possess a wide range of bioactivities. The burst of synthetic biology technology facilitates the discovery of new thiol-containing active ingredients. Herein, we report a sensitive, quick, and robust surface-enhanced Raman scattering technology for specific and multiplex detection of thiol-containing compounds without purification requirements and also indicating the thiols with different chemical environments. Using this platform, we successfully demonstrated the simultaneous detection of thiol-containing compounds from as low as 1??M of analytes spiked in complex culture matrices.

SUBMITTER: Hong Y

PROVIDER: S-EPMC7416272 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Rapid SERS Detection of Thiol-Containing Natural Products in Culturing Complex.

Hong Yan Y Wang Rui R Jiang Zhuoran Z Cong Zisong Z Song Heng H

International journal of analytical chemistry 20200801

Thiol-containing natural products possess a wide range of bioactivities. The burst of synthetic biology technology facilitates the discovery of new thiol-containing active ingredients. Herein, we report a sensitive, quick, and robust surface-enhanced Raman scattering technology for specific and multiplex detection of thiol-containing compounds without purification requirements and also indicating the thiols with different chemical environments. Using this platform, we successfully demonstrated t ...[more]

PMID: 32802063

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