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Advanced lipoprotein profile disturbances in type 1 diabetes mellitus: a focus on LDL particles.


ABSTRACT: BACKGROUND:Lipoprotein disturbances have been associated with increased cardiovascular disease (CVD) risk in type 1 diabetes mellitus (T1DM). We assessed the advanced lipoprotein profile in T1DM individuals, and analysed differences with non-diabetic counterparts. METHODS:This cross-sectional study involved 508 adults with T1DM and 347 controls, recruited from institutions in a Mediterranean region of Spain. Conventional and advanced (assessed by nuclear magnetic resonance [NMR] spectroscopy) lipoprotein profiles were analysed. Crude and adjusted (by age, sex, statin use, body mass index and leukocyte count) comparisons were performed. RESULTS:The median (interquartile range) age of the study participants was 45 (38-53) years, 48.2% were men. In the T1DM group, the median diabetes duration was 23 (16-31) years, and 8.1% and 40.2% of individuals had nephropathy and retinopathy, respectively. The proportion of participants with hypertension (29.5 vs. 9.2%), and statin use (45.7% vs. 8.1%) was higher in the T1DM vs. controls (p??1000 nmol/L: 38 vs. 21.2%; p?

SUBMITTER: Amor AJ 

PROVIDER: S-EPMC7416413 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Advanced lipoprotein profile disturbances in type 1 diabetes mellitus: a focus on LDL particles.

Amor Antonio J AJ   Castelblanco Esmeralda E   Hernández Marta M   Gimenez Marga M   Granado-Casas Minerva M   Blanco Jesús J   Soldevila Berta B   Esmatjes Enric E   Conget Ignacio I   Alonso Nuria N   Ortega Emilio E   Mauricio Didac D  

Cardiovascular diabetology 20200809 1


<h4>Background</h4>Lipoprotein disturbances have been associated with increased cardiovascular disease (CVD) risk in type 1 diabetes mellitus (T1DM). We assessed the advanced lipoprotein profile in T1DM individuals, and analysed differences with non-diabetic counterparts.<h4>Methods</h4>This cross-sectional study involved 508 adults with T1DM and 347 controls, recruited from institutions in a Mediterranean region of Spain. Conventional and advanced (assessed by nuclear magnetic resonance [NMR] s  ...[more]

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