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Host Polymorphisms May Impact SARS-CoV-2 Infectivity.

ABSTRACT: Based on a broad public database compilation, we support the hypothesis that germinal polymorphisms may regulate the expression of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cellular target itself and proteases controlling the process of its shedding or, conversely, its internalization. Consequently, a genetic influence on individual susceptibility to coronavirus disease 2019 (COVID-19) infection is strongly suspected.

SUBMITTER: Brest P

PROVIDER: S-EPMC7416730 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Host Polymorphisms May Impact SARS-CoV-2 Infectivity.

Brest Patrick P Refae Sadal S Mograbi Baharia B Hofman Paul P Milano Gerard G

Trends in genetics : TIG 20200810 11

Based on a broad public database compilation, we support the hypothesis that germinal polymorphisms may regulate the expression of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cellular target itself and proteases controlling the process of its shedding or, conversely, its internalization. Consequently, a genetic influence on individual susceptibility to coronavirus disease 2019 (COVID-19) infection is strongly suspected. ...[more]

PMID: 32828550

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