Ontology highlight
ABSTRACT:
SUBMITTER: Suzuki K
PROVIDER: S-EPMC7416950 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Suzuki Katsushi K Matsumoto Mitsuyo M Katoh Yasutake Y Liu Liang L Ochiai Kyoko K Aizawa Yuta Y Nagatomi Ryoichi R Okuno Hiroshi H Itoi Eiji E Igarashi Kazuhiko K
PloS one 20200810 8
It has been reported that Bach1-deficient mice show reduced tissue injuries in diverse disease models due to increased expression of heme oxygenase-1 (HO-1)that possesses an antioxidant function. In contrast, we found that Bach1 deficiency in mice exacerbated skeletal muscle injury induced by cardiotoxin. Inhibition of Bach1 expression in C2C12 myoblast cells using RNA interference resulted in reduced proliferation, myotube formation, and myogenin expression compared with control cells. While th ...[more]