Ontology highlight
ABSTRACT:
SUBMITTER: Arbe MF
PROVIDER: S-EPMC7417947 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Arbe María Florencia MF Agnetti Lucrecia L Breininger Elizabeth E Glikin Gerardo Claudio GC Finocchiaro Liliana María Elena LME Villaverde Marcela Solange MS
Translational oncology 20200808 11
Most cancer cells exacerbate the pentose phosphate pathway (PPP) to enhance biosynthetic precursors and antioxidant defenses. Metformin, which is used as a first-line oral drug for the treatment of type 2 diabetes, has been proposed to inhibit the malignant progression of different types of cancers. However, metformin has shown poor efficacy as single agent in several clinical trials. Thus, the aim of the present work was to investigate whether the pharmacological inhibition of G6PDH, the first ...[more]