Ontology highlight
ABSTRACT:
SUBMITTER: Zhang M
PROVIDER: S-EPMC4966316 | biostudies-other | 2016 Aug
REPOSITORIES: biostudies-other
Zhang Minjie M Mani Sriniwasan B SB He Yao Y Hall Amber M AM Xu Lin L Li Yefu Y Zurakowski David D Jay Gregory D GD Warman Matthew L ML
The Journal of clinical investigation 20160718 8
Joints that have degenerated as a result of aging or injury contain dead chondrocytes and damaged cartilage. Some studies have suggested that chondrocyte death precedes cartilage damage, but how the loss of chondrocytes affects cartilage integrity is not clear. In this study, we examined whether chondrocyte death undermines cartilage integrity in aging and injury using a rapid 3D confocal cartilage imaging technique coupled with standard histology. We induced autonomous expression of diphtheria ...[more]