Ontology highlight
ABSTRACT:
SUBMITTER: Larkin IN
PROVIDER: S-EPMC7418077 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Larkin Isaac N IN Garimella Viswanadham V Yamankurt Gokay G Scott Alexander W AW Xing Hang H Mirkin Chad A CA
Analytical chemistry 20200521 11
We report a dual-readout, AuNP-based sandwich immunoassay for the device-free colorimetric and sensitive scanometric detection of disease biomarkers. An AuNP-antibody conjugate serves as a signal transduction and amplification agent by promoting the reduction and deposition of either platinum or gold onto its surface, generating corresponding colorimetric or light scattering (scanometric) signals, respectively. We apply the Pt-based colorimetric readout of this assay to the discovery of a novel ...[more]