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A phenome-wide association study (PheWAS) of COVID-19 outcomes by race using the electronic health records data in Michigan Medicine.

ABSTRACT: We perform a phenome-wide scan to identify pre-existing conditions related to COVID-19 susceptibility and prognosis across the medical phenome and how they vary by race. The study is comprised of 53,853 patients who were tested/positive for COVID-19 between March 10 and September 2, 2020 at a large academic medical center. Pre-existing conditions strongly associated with hospitalization were renal failure, pulmonary heart disease, and respiratory failure. Hematopoietic conditions were associated with ICU admission/mortality and mental disorders were associated with mortality in non-Hispanic Whites. Circulatory system and genitourinary conditions were associated with ICU admission/mortality in non-Hispanic Blacks. Understanding pre-existing clinical diagnoses related to COVID-19 outcomes informs the need for targeted screening to support specific vulnerable populations to improve disease prevention and healthcare delivery.

SUBMITTER: Salvatore M

PROVIDER: S-EPMC7418740 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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A phenome-wide association study (PheWAS) of COVID-19 outcomes by race using the electronic health records data in Michigan Medicine.

Salvatore Maxwell M Gu Tian T Mack Jasmine A JA Sankar Swaraaj Prabhu SP Patil Snehal S Valley Thomas S TS Singh Karandeep K Nallamothu Brahmajee K BK Kheterpal Sachin S Lisabeth Lynda L Fritsche Lars G LG Mukherjee Bhramar B

medRxiv : the preprint server for health sciences 20210220

<h4>Background</h4>We perform a phenome-wide scan to identify pre-existing conditions related to COVID-19 susceptibility and prognosis across the medical phenome and how they vary by race.<h4>Methods</h4>The study is comprised of 53,853 patients who were tested/positive for COVID-19 between March 10 and September 2, 2020 at a large academic medical center.<h4>Results</h4>Pre-existing conditions strongly associated with hospitalization were <i>renal failure, pulmonary heart disease</i>, and <i>re ...[more]

PMID: 32793923

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Dataset Information

A phenome-wide association study (PheWAS) of COVID-19 outcomes by race using the electronic health records data in Michigan Medicine.

Publications

A phenome-wide association study (PheWAS) of COVID-19 outcomes by race using the electronic health records data in Michigan Medicine.

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