Dataset Information

A Phenome-Wide Association Study (PheWAS) of COVID-19 Outcomes by Race Using the Electronic Health Records Data in Michigan Medicine.

ABSTRACT: We performed a phenome-wide association study to identify pre-existing conditions related to Coronavirus disease 2019 (COVID-19) prognosis across the medical phenome and how they vary by race. The study is comprised of 53,853 patients who were tested/diagnosed for COVID-19 between 10 March and 2 September 2020 at a large academic medical center. Pre-existing conditions strongly associated with hospitalization were renal failure, pulmonary heart disease, and respiratory failure. Hematopoietic conditions were associated with intensive care unit (ICU) admission/mortality and mental disorders were associated with mortality in non-Hispanic Whites. Circulatory system and genitourinary conditions were associated with ICU admission/mortality in non-Hispanic Blacks. Understanding pre-existing clinical diagnoses related to COVID-19 outcomes informs the need for targeted screening to support specific vulnerable populations to improve disease prevention and healthcare delivery.

SUBMITTER: Salvatore M

PROVIDER: S-EPMC8037108 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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A Phenome-Wide Association Study (PheWAS) of COVID-19 Outcomes by Race Using the Electronic Health Records Data in Michigan Medicine.

Salvatore Maxwell M Gu Tian T Mack Jasmine A JA Prabhu Sankar Swaraaj S Patil Snehal S Valley Thomas S TS Singh Karandeep K Nallamothu Brahmajee K BK Kheterpal Sachin S Lisabeth Lynda L Fritsche Lars G LG Mukherjee Bhramar B

Journal of clinical medicine 20210325 7

<h4>Background</h4>We performed a phenome-wide association study to identify pre-existing conditions related to Coronavirus disease 2019 (COVID-19) prognosis across the medical phenome and how they vary by race.<h4>Methods</h4>The study is comprised of 53,853 patients who were tested/diagnosed for COVID-19 between 10 March and 2 September 2020 at a large academic medical center.<h4>Results</h4>Pre-existing conditions strongly associated with hospitalization were renal failure, pulmonary heart di ...[more]

PMID: 33805886

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Dataset Information

A Phenome-Wide Association Study (PheWAS) of COVID-19 Outcomes by Race Using the Electronic Health Records Data in Michigan Medicine.

Publications

A Phenome-Wide Association Study (PheWAS) of COVID-19 Outcomes by Race Using the Electronic Health Records Data in Michigan Medicine.

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