Ontology highlight
ABSTRACT:
SUBMITTER: Wright WC
PROVIDER: S-EPMC7418881 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Wright William C WC Chenge Jude J Chen Taosheng T
Liver research 20190829 3-4
Cytochrome P450 enzymes function to catalyze a wide range of reactions, many of which are critically important for drug response. Members of the human cytochrome P450 3A (CYP3A) family are particularly important in drug clearance, and they collectively metabolize more than half of all currently prescribed medications. The ability of these enzymes to bind a large and structurally diverse set of compounds increases the chances of their modulating or facilitating drug metabolism in unfavorable ways ...[more]