Ontology highlight
ABSTRACT:
SUBMITTER: Cantsilieris S
PROVIDER: S-EPMC7419210 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Cantsilieris Stuart S Sunkin Susan M SM Johnson Matthew E ME Anaclerio Fabio F Huddleston John J Baker Carl C Dougherty Max L ML Underwood Jason G JG Sulovari Arvis A Hsieh PingHsun P Mao Yafei Y Catacchio Claudia Rita CR Malig Maika M Welch AnneMarie E AE Sorensen Melanie M Munson Katherine M KM Jiang Weihong W Girirajan Santhosh S Ventura Mario M Lamb Bruce T BT Conlon Ronald A RA Eichler Evan E EE
Genome biology 20200810 1
<h4>Background</h4>The complex interspersed pattern of segmental duplications in humans is responsible for rearrangements associated with neurodevelopmental disease, including the emergence of novel genes important in human brain evolution. We investigate the evolution of LCR16a, a putative driver of this phenomenon that encodes one of the most rapidly evolving human-ape gene families, nuclear pore interacting protein (NPIP).<h4>Results</h4>Comparative analysis shows that LCR16a has independentl ...[more]