Ontology highlight
ABSTRACT:
SUBMITTER: Yu DH
PROVIDER: S-EPMC7419686 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Yu De-Hua DH Xu Zhi-Yuan ZY Mo Shaowei S Yuan Li L Cheng Xiang-Dong XD Qin Jiang-Jiang JJ
Frontiers in oncology 20200805
The oncogene MDMX, also known as MDM4 is a critical negative regulator of the tumor suppressor p53 and has been implicated in the initiation and progression of human cancers. Increasing evidence indicates that MDMX is often amplified and highly expressed in human cancers, promotes cancer cell growth, and inhibits apoptosis by dampening p53-mediated transcription of its target genes. Inhibiting MDMX-p53 interaction has been found to be effective for restoring the tumor suppressor activity of p53. ...[more]