Ontology highlight
ABSTRACT:
SUBMITTER: Tseliou V
PROVIDER: S-EPMC7422701 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Tseliou Vasilis V Knaus Tanja T Vilím Jan J Masman Marcelo F MF Mutti Francesco G FG
ChemCatChem 20200306 8
A NADH-dependent engineered amine dehydrogenase from <i>Geobacillus stearothermophilus</i> (LE-AmDH-v1) was applied together with a NADH-oxidase from <i>Streptococcus mutans</i> (NOx) for the kinetic resolution of pharmaceutically relevant racemic α-chiral primary amines. The reaction conditions (e. g., pH, temperature, type of buffer) were optimised to yield <i>S</i>-configured amines with up to >99 % <i>ee</i>. ...[more]