Ontology highlight
ABSTRACT:
SUBMITTER: Hooftman A
PROVIDER: S-EPMC7422798 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Hooftman Alexander A Angiari Stefano S Hester Svenja S Corcoran Sarah E SE Runtsch Marah C MC Ling Chris C Ruzek Melanie C MC Slivka Peter F PF McGettrick Anne F AF Banahan Kathy K Hughes Mark M MM Irvine Alan D AD Fischer Roman R O'Neill Luke A J LAJ
Cell metabolism 20200812 3
The Krebs cycle-derived metabolite itaconate is highly upregulated in inflammatory macrophages and exerts immunomodulatory effects through cysteine modifications on target proteins. The NLRP3 inflammasome, which cleaves IL-1β, IL-18, and gasdermin D, must be tightly regulated to avoid excessive inflammation. Here we provide evidence that itaconate modifies NLRP3 and inhibits inflammasome activation. Itaconate and its derivative, 4-octyl itaconate (4-OI), inhibited NLRP3 inflammasome activation, ...[more]