Unknown

Dataset Information

0

Extracellular vesicle-encapsulated IL-10 as novel nanotherapeutics against ischemic AKI.


ABSTRACT: Recently, extracellular vesicles (EVs) have been attracting strong research interest for use as natural drug delivery systems. We report an approach to manufacturing interleukin-10 (IL-10)-loaded EVs (IL-10+ EVs) by engineering macrophages for treating ischemic acute kidney injury (AKI). Delivery of IL-10 via EVs enhanced not only the stability of IL-10, but also its targeting to the kidney due to the adhesive components on the EV surface. Treatment with IL-10+ EVs significantly ameliorated renal tubular injury and inflammation caused by ischemia/reperfusion injury, and potently prevented the transition to chronic kidney disease. Mechanistically, IL-10+ EVs targeted tubular epithelial cells, and suppressed mammalian target of rapamycin signaling, thereby promoting mitophagy to maintain mitochondrial fitness. Moreover, IL-10+ EVs efficiently drove M2 macrophage polarization by targeting macrophages in the tubulointerstitium. Our study demonstrates that EVs can serve as a promising delivery platform to manipulate IL-10 for the effective treatment of ischemic AKI.

SUBMITTER: Tang TT 

PROVIDER: S-EPMC7423360 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC10999083 | biostudies-literature
| S-EPMC10787844 | biostudies-literature
| S-EPMC7381724 | biostudies-literature
| S-EPMC3785280 | biostudies-literature
| S-EPMC3582209 | biostudies-literature
| S-EPMC6942436 | biostudies-literature
| S-EPMC9318050 | biostudies-literature
| S-EPMC4657830 | biostudies-literature
| S-EPMC7786507 | biostudies-literature
| S-EPMC8416368 | biostudies-literature