Ontology highlight
ABSTRACT:
SUBMITTER: Banks GT
PROVIDER: S-EPMC7423362 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Banks Gareth T GT Guillaumin Mathilde C C MCC Heise Ines I Lau Petrina P Yin Minghui M Bourbia Nora N Aguilar Carlos C Bowl Michael R MR Esapa Chris C Brown Laurence A LA Hasan Sibah S Tagliatti Erica E Nicholson Elizabeth E Bains Rasneer Sonia RS Wells Sara S Vyazovskiy Vladyslav V VV Volynski Kirill K Peirson Stuart N SN Nolan Patrick M PM
Science advances 20200812 33
Switches between global sleep and wakefulness states are believed to be dictated by top-down influences arising from subcortical nuclei. Using forward genetics and in vivo electrophysiology, we identified a recessive mouse mutant line characterized by a substantially reduced propensity to transition between wake and sleep states with an especially pronounced deficit in initiating rapid eye movement (REM) sleep episodes. The causative mutation, an Ile102Asn substitution in the synaptic vesicular ...[more]