Ontology highlight
ABSTRACT:
SUBMITTER: Moisio O
PROVIDER: S-EPMC7423886 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Moisio Olli O Palani Senthil S Virta Jenni J Elo Petri P Liljenbäck Heidi H Tolvanen Tuula T Käkelä Meeri M Miner Maxwell G MG Herre Erika Atencio EA Marjamäki Päivi P Örd Tiit T Heinäniemi Merja M Kaikkonen Minna U MU Zhang Fenghua F Srinivasarao Madduri M Knuuti Juhani J Low Philip S PS Saraste Antti A Li Xiang-Guo XG Roivainen Anne A
Scientific reports 20200812 1
Folate receptor β (FR-β), a marker expressed on macrophages, is a promising target for imaging of inflammation. Here, we report the radiosynthesis and preclinical evaluation of [<sup>68</sup>Ga]Ga-NOTA-folate (<sup>68</sup>Ga-FOL). After determining the affinity of <sup>68</sup>Ga-FOL using cells expressing FR-β, we studied atherosclerotic mice with <sup>68</sup>Ga-FOL and <sup>18</sup>F-FDG PET/CT. In addition, we studied tracer distribution and co-localization with macrophages in aorta cryosec ...[more]