Dataset Information

New 8-O-4' Neolignans and Their Antibacterial Activity from the Whole Plants of Clematis lasiandra.

ABSTRACT: Four new 8-O-4' neolignans, characterized at methoxy or ethoxy groups substituted at C-7, namely, (±) lasiandranins A-D (1-4), and two known analogs (±) pinnatifidanin BV (5) and (±) pinnatifidanin BVI (6) were isolated from the whole plants of Clematis lasiandra Maxim. The structures of 1-6 were determined by spectroscopic methods including 1D, 2D NMR, ECD, and HRESIMS analysis. Compounds 1 and 5 were determined as erythro configuration, while 2-4 and 6 were determined as threo configuration based on the chemical shift difference of H-9a and H-9b in CD3OD. The 8-O-4' neolignans were found from the genus Clematis for the first time. Compounds 1-6 were evaluated for their antibacterial activity against three plant pathogenic bacteria Pseudomonas syringae pv. actinidiae, Ralstonia solanacearum, and Erwinia carotovora by agar and broth dilution methods. Compounds 1-6 showed potent antibacterial activity against R. solanacearum with MIC values of 25-50 ?g/mL and relatively lower activity against P. syringae pv. actinidiae with MIC values of 50-100 ?g/mL, while they were inactive to E. carotovora.

SUBMITTER: Hao N

PROVIDER: S-EPMC7424705 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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New 8-O-4' Neolignans and Their Antibacterial Activity from the Whole Plants of Clematis lasiandra.

Hao Nan N Han Lirong L Li Yantao Y Li Jiao J Tian Xiaolin X Kong Dan D Tian Xiangrong X

ACS omega 20200727 31

Four new 8-O-4' neolignans, characterized at methoxy or ethoxy groups substituted at C-7, namely, (±) lasiandranins A-D (1-4), and two known analogs (±) pinnatifidanin BV (5) and (±) pinnatifidanin BVI (6) were isolated from the whole plants of Clematis lasiandra Maxim. The structures of 1-6 were determined by spectroscopic methods including 1D, 2D NMR, ECD, and HRESIMS analysis. Compounds 1 and 5 were determined as erythro co ...[more]

PMID: 32803061

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Project description:Myanmar has a rich pool of, but less known, medicinal plants with traditional knowledge. In this study, we aimed to investigate the inhibitory activity of traditional Myanmar medicinal plants against the type III secretion system (T3SS) of Salmonella enterica serovar Typhimurium UK-1 χ8956 and the intestinal disease-caused by microbes including S. enterica serovar Typhimurium UK-1 χ8956, Proteusbacillus vulgaris CPCC 160013, Escherichia coli CICC 10003, and Staphylococcus aureus ATCC 25923. The EtOH extracts of 93 samples were used to screen the inhibitory activities against the secretion of T3SS effector proteins SipA/B/C/D of S. enterica and the antibacterial activity against S. enterica, P. vulgaris, E. coli, and S. aureus. Out of 71 crude drugs traditionally used, 18 were proofed to be effective either on the growth inhibition of tested bacteria and/or as inhibitors for the T3SS. The EtOH extracts of five plants, Luvunga scandens (Roxb.) Buch.-Ham. ex Wight & Arn. (My7), Myrica nagi Thunb. (My11), Terminalia citrina Roxb. ex Fleming (My21), Thymus vulgaris L. (My49), and Cinnamomum bejolghota (Buch.-Ham.) Sweet (My104), showed potent inhibitory activities against the secretion of T3SS proteins SipA/B/C/D of S. enterica serovar Typhimurium UK-1 χ 8956. Mansonia gagei J.R.Drumm (My3) and Mesua ferrea (Roxb.) L. (My10) showed strong antibacterial activities against P. vulgaris and S. aureus. This study provided the first scientific evidence of T3SS prohibiting and antibacterial properties for the traditional knowledge in Myanmar of using plants as medicines for treating infections and gastrointestinal disease. Further researches are proposed to discover the active chemical compounds and mechanism of L. scandens (Roxb.) Buch.-Ham. ex Wight & Arn, M. nagi Thunb., T. citrina Roxb. ex Fleming, T. vulgaris L., and C. bejolghota (Buch.-Ham.) Sweet as antivirulence drugs and the potential of M. gagei J.R.Drumm and M. ferrea L. as new broad spectrum plant antibiotics.

Dataset Information

New 8-O-4' Neolignans and Their Antibacterial Activity from the Whole Plants of Clematis lasiandra.

Publications

New 8-O-4' Neolignans and Their Antibacterial Activity from the Whole Plants of <i>Clematis lasiandra</i>.

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