Ontology highlight
ABSTRACT:
SUBMITTER: Mourad AAE
PROVIDER: S-EPMC7425103 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Drug design, development and therapy 20200803
<h4>Introduction</h4>In order to develop novel anticancer HDAC/tubulin dual inhibitors, a novel series of α-phthalimido-substituted chalcones-based hybrids was synthesized and characterized by IR, <sup>1</sup>H NMR, <sup>13</sup>C NMR, mass spectroscopy and X-ray analysis.<h4>Methods</h4>All the synthesized compounds were evaluated for their in vitro anticancer activity against MCF-7 and HepG2 human cancer cell lines using MTT assay. To explore the mechanism of action of the synthesized compound ...[more]