Ontology highlight
ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC7426619 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Wang Xiaobo X Wu Tengteng T Zhang Jinru J Guo Gongbo G He XiaoFei X Pei Zhong Z Liu Zhaohui Z Liu Chun-Feng CF Ross Christopher A CA Smith Wanli W WW
Frontiers in aging neuroscience 20200807
Mutations in transmembrane protein 230 (TMEM230) gene are suggested to be associated with the autosomal dominant Parkinson's disease (PD) with typical movement disorders and Lewy body pathology. However, the normal functions and the pathological roles of TMEM230 are not clear. In this study, we used TMEM230 isoform II constructs including wild-type (WT) and four reported PD-linked mutation constructs (Y92C, R141L, 184Wext*5, and 184PGext*5). Ectopic expression of WT and PD-linked mutant TMEM230 ...[more]