Ontology highlight
ABSTRACT:
SUBMITTER: Harmouch E
PROVIDER: S-EPMC7426813 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Harmouch Ezeddine E Seitlinger Joseph J Chaddad Hassan H Ubeaud-Sequier Geneviève G Barths Jochen J Saidu Sani S Désaubry Laurent L Grandemange Stéphanie S Massfelder Thierry T Fuhrmann Guy G Fioretti Florence F Dontenwill Monique M Benkirane-Jessel Nadia N Idoux-Gillet Ysia Y
Scientific reports 20200813 1
Glioblastoma (GBM) is one of the most aggressive types of cancer, which begins within the brain. It is the most invasive type of glioma developed from astrocytes. Until today, Temozolomide (TMZ) is the only standard chemotherapy for patients with GBM. Even though chemotherapy extends the survival of patients, there are many undesirable side effects, and most cases show resistance to TMZ. FL3 is a synthetic flavagline which displays potent anticancer activities, and is known to inhibit cell proli ...[more]