Ontology highlight
ABSTRACT:
SUBMITTER: Liu R
PROVIDER: S-EPMC7426931 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Nature communications 20200813 1
Regulatory networks describe the hierarchical relationship between transcription factors, associated proteins, and their target genes. Regulatory networks respond to environmental and genetic perturbations by reprogramming cellular metabolism. Here we design, construct, and map a comprehensive regulatory network library containing 110,120 specific mutations in 82 regulators expected to perturb metabolism. We screen the library for different targeted phenotypes, and identify mutants that confer s ...[more]