Ontology highlight
ABSTRACT:
SUBMITTER: Olafsson S
PROVIDER: S-EPMC7427325 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Olafsson Sigurgeir S McIntyre Rebecca E RE Coorens Tim T Butler Timothy T Jung Hyunchul H Robinson Philip S PS Lee-Six Henry H Sanders Mathijs A MA Arestang Kenneth K Dawson Claire C Tripathi Monika M Strongili Konstantina K Hooks Yvette Y Stratton Michael R MR Parkes Miles M Martincorena Inigo I Raine Tim T Campbell Peter J PJ Anderson Carl A CA
Cell 20200721 3
Inflammatory bowel disease (IBD) is a chronic inflammatory disease associated with increased risk of gastrointestinal cancers. We whole-genome sequenced 446 colonic crypts from 46 IBD patients and compared these to 412 crypts from 41 non-IBD controls from our previous publication on the mutation landscape of the normal colon. The average mutation rate of affected colonic epithelial cells is 2.4-fold that of healthy colon, and this increase is mostly driven by acceleration of mutational processes ...[more]