Interleukin-27 Functional Duality Balances Leishmania Infectivity and Pathogenesis.
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ABSTRACT:
SUBMITTER: Jafarzadeh A
PROVIDER: S-EPMC7427467 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
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Interleukin-27 Functional Duality Balances <i>Leishmania</i> Infectivity and Pathogenesis.
Jafarzadeh Abdollah A Nemati Maryam M Chauhan Prashant P Patidar Ashok A Sarkar Arup A Sharifi Iraj I Saha Bhaskar B
Frontiers in immunology 20200807
IL-27 is a cytokine that exerts diverse effects on the cells of innate and adaptive immune systems. Chiefly expressed in macrophages and dendritic cells during the early phase of Leishmania infection, IL-27 contributes to the protection against L. major infection but suppresses the protective Th1 response against L. donovani, L. infantum, L. amazonensis and L. braziliensis infections, suggesting its functional duality. During the late stage of Leishmania infection, IL-27 limits the immunopathoge ...[more]
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