Ontology highlight
ABSTRACT:
SUBMITTER: Sekine T
PROVIDER: S-EPMC7427556 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Cell 20200814 1
SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune protection against COVID-19. Here, we systematically mapped the functional and phenotypic landscape of SARS-CoV-2-specific T cell responses in unexposed individuals, exposed family members, and individuals with acute or convalescent COVID-19. Acute-phase SARS-CoV-2-specific T cells displayed a highly activated cytotoxic phenotype that correlated with various clinical markers of disease severity, whereas convalesce ...[more]