Unknown

Dataset Information

0

A single dose of an adenovirus-vectored vaccine provides protection against SARS-CoV-2 challenge.

ABSTRACT: The unprecedented coronavirus disease 2019 (COVID-19) epidemic has created a worldwide public health emergency, and there is an urgent need to develop an effective vaccine to control this severe infectious disease. Here, we find that a single vaccination with a replication-defective human type 5 adenovirus encoding the SARS-CoV-2 spike protein (Ad5-nCoV) protect mice completely against mouse-adapted SARS-CoV-2 infection in the upper and lower respiratory tracts. Additionally, a single vaccination with Ad5-nCoV protects ferrets from wild-type SARS-CoV-2 infection in the upper respiratory tract. This study suggests that the mucosal vaccination may provide a desirable protective efficacy and this delivery mode is worth further investigation in human clinical trials.

SUBMITTER: Wu S 

PROVIDER: S-EPMC7427994 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

The unprecedented coronavirus disease 2019 (COVID-19) epidemic has created a worldwide public health emergency, and there is an urgent need to develop an effective vaccine to control this severe infectious disease. Here, we find that a single vaccination with a replication-defective human type 5 adenovirus encoding the SARS-CoV-2 spike protein (Ad5-nCoV) protect mice completely against mouse-adapted SARS-CoV-2 infection in the upper and lower respiratory tracts. Additionally, a single vaccinatio  ...[more]

Similar Datasets

Unknown Single-dose of a replication-competent adenovirus-vectored vaccine provides sterilizing protection against Rift Valley fever virus challenge.
| S-EPMC9691644 | biostudies-literature
Unknown An adenovirus-vectored COVID-19 vaccine confers protection from SARS-COV-2 challenge in rhesus macaques.
| S-EPMC7442803 | biostudies-literature
Unknown A single dose of recombinant VSV-?G-spike vaccine provides protection against SARS-CoV-2 challenge.
| S-EPMC7745033 | biostudies-literature
Unknown Alphavirus-vectored hemagglutinin subunit vaccine provides partial protection against heterologous challenge in pigs.
| S-EPMC6990457 | biostudies-literature
Unknown An adenovirus-vectored RVF vaccine confers complete protection against lethal RVFV challenge in A129 mice.
| S-EPMC10011166 | biostudies-literature
Unknown A single intranasal dose of chimpanzee adenovirus-vectored vaccine protects against SARS-CoV-2 infection in rhesus macaques.
| S-EPMC7969912 | biostudies-literature
Unknown One dose of COVID-19 nanoparticle vaccine REVC-128 provides protection against SARS-CoV-2 challenge at two weeks post immunization.
| S-EPMC8567933 | biostudies-literature
Unknown Adenovirus-Vectored Vaccine Provides Postexposure Protection to Ebola Virus-Infected Nonhuman Primates.
| S-EPMC4564535 | biostudies-literature
Unknown Prefusion-stabilized SARS-CoV-2 S2-only antigen provides protection against SARS-CoV-2 challenge.
| S-EPMC10879192 | biostudies-literature
Unknown Protection of chickens against avian influenza with non-replicating adenovirus-vectored vaccine.
| S-EPMC2720404 | biostudies-literature