Ontology highlight
ABSTRACT:
SUBMITTER: Wu S
PROVIDER: S-EPMC7427994 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Wu Shipo S Zhong Gongxun G Zhang Jun J Shuai Lei L Zhang Zhe Z Wen Zhiyuan Z Wang Busen B Zhao Zhenghao Z Song Xiaohong X Chen Yi Y Liu Renqiang R Fu Ling L Zhang Jinlong J Guo Qiang Q Wang Chong C Yang Yilong Y Fang Ting T Lv Peng P Wang Jinliang J Xu Junjie J Li Jianmin J Yu Changming C Hou Lihua L Bu Zhigao Z Chen Wei W
Nature communications 20200814 1
The unprecedented coronavirus disease 2019 (COVID-19) epidemic has created a worldwide public health emergency, and there is an urgent need to develop an effective vaccine to control this severe infectious disease. Here, we find that a single vaccination with a replication-defective human type 5 adenovirus encoding the SARS-CoV-2 spike protein (Ad5-nCoV) protect mice completely against mouse-adapted SARS-CoV-2 infection in the upper and lower respiratory tracts. Additionally, a single vaccinatio ...[more]