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Hydrolysis-resistant and stress-buffering bifunctional polyurethane adhesive for durable dental composite restoration.

ABSTRACT: A new elastic polyurethane (PU) adhesive was reported in this study to improve the stability and durability of the dental adhesion interface. A polyurethane oligomer was synthesized by the solution polymerization method, and a diluent and solvent were added to prepare PU adhesives. The water sorption, water solubility, contact angle, thermal stability, degree of conversion and mechanical properties of the PU adhesives were evaluated. Experimental applications for tooth restoration (microtensile bond strength and microleakage) were also performed, and cytotoxicity test was carried out. The water sorption and solubility of the PU adhesives were significantly lower than those of three commercial adhesives. The microtensile bond strength of the PU adhesives was improved after thermocycling test, and the extent of microleakage was diminished when compared with that of commercial adhesives. Biocompatibility testing demonstrated that the PU adhesive was non-toxic to L929 fibroblasts. This study shows the ability of PU adhesive to improve the stability and durability of the dental adhesion interface and may refocus the attention of scientists from rigid bonding to flexible bonding for dental adhesion, and it sheds light on a new strategy for the stable and durable bonding interface of dentine adhesives.

SUBMITTER: Zhang J

PROVIDER: S-EPMC7428285 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Hydrolysis-resistant and stress-buffering bifunctional polyurethane adhesive for durable dental composite restoration.

Zhang Jiahui J Guo Xiaowei X Zhang Xiaomeng X Wang Huimin H Zhu Jiufu J Shi Zuosen Z Zhu Song S Cui Zhanchen Z

Royal Society open science 20200708 7

A new elastic polyurethane (PU) adhesive was reported in this study to improve the stability and durability of the dental adhesion interface. A polyurethane oligomer was synthesized by the solution polymerization method, and a diluent and solvent were added to prepare PU adhesives. The water sorption, water solubility, contact angle, thermal stability, degree of conversion and mechanical properties of the PU adhesives were evaluated. Experimental applications for tooth restoration (microtensile ...[more]

PMID: 32874639

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Project description:ObjectiveAssess the ability of an antimicrobial drug-releasing resin adhesive, containing octenidine dihydrochloride (OCT)-silica co-assembled particles (DSPs), to enhance the biostability and preserve the interfacial fracture toughness (FT) of composite restorations bonded to dentin. Enzyme-catalyzed degradation compromises the dental restoration-tooth interface, increasing cariogenic bacterial infiltration. In addition to bacterial ingress inhibition, antimicrobial-releasing adhesives may exhibit direct interfacial biodegradation inhibition as an additional benefit.MethodsMini short-rod restoration bonding specimens with total-etch adhesive with/without 10% wt. DSPs were made. Interfacial fracture toughness (FT) was measured as-manufactured or post-incubation in simulated human salivary esterase (SHSE) for up to 6-months. Effect of OCT on SHSE and whole saliva/bacterial enzyme activity was assessed. Release of OCT outside the restoration interface was assessed.ResultsNo deleterious effect of DSPs on initial bonding capacity was observed. Aging specimens in SHSE reduced FT of control but not DSP-adhesive-bonded specimens. OCT inhibited SHSE degradation of adhesive monomer and may inhibit endogenous proteases. OCT inhibited bacterial esterase and collagenase. No endogenous collagen breakdown was detected in the present study. OCT increased human saliva degradative esterase activity below its minimum inhibitory concentration towards S. mutans (MIC), but inhibited degradation above MIC. OCT release outside restoration margins was below detection.SignificanceDSP-adhesive preserves the restoration bond through a secondary enzyme-inhibitory effect of released OCT, which is virtually confined to the restoration interface microgap. Enzyme activity modulation may produce a positive-to-negative feedback switch, by increasing OCT concentration via biodegradation-triggered release to an effective dose, then subsequently slowing degradation and degradation-triggered release.

Dataset Information

Hydrolysis-resistant and stress-buffering bifunctional polyurethane adhesive for durable dental composite restoration.

Publications

Hydrolysis-resistant and stress-buffering bifunctional polyurethane adhesive for durable dental composite restoration.

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