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Severe ineffective erythropoiesis discriminates prognosis in myelodysplastic syndromes: analysis based on 776 patients from a single centre.


ABSTRACT: The underlying mechanisms and clinical significance of ineffective erythropoiesis in myelodysplastic syndromes (MDS) remain to be fully defined. We conducted the ex vivo erythroid differentiation of megakaryocytic-erythroid progenitors (MEPs) from MDS patients and discovered that patient-derived erythroblasts exhibit precocity and premature aging phenotypes, partially by inducing the pro-aging genes, like ERCC1. Absolute reticulocyte count (ARC) was chosen as a biomarker to evaluate the severity of ineffective erythropoiesis in 776 MDS patients. We found that patients with severe ineffective erythropoiesis displaying lower ARC (<20?×?109/L), were more likely to harbor complex karyotypes and high-risk somatic mutations (p?

SUBMITTER: Huang H 

PROVIDER: S-EPMC7429953 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Severe ineffective erythropoiesis discriminates prognosis in myelodysplastic syndromes: analysis based on 776 patients from a single centre.

Huang Huijun H   Xu Changlu C   Gao Jie J   Li Bing B   Qin Tiejun T   Xu Zefeng Z   Ren Sirui S   Zhang Yudi Y   Jiao Meng M   Qu Shiqiang S   Pan Lijuan L   Hu Naibo N   Liu Jinqin J   Cai Wenyu W   Zhang Yingnan Y   Wu Dan D   Zhang Peihong P   Gale Robert Peter RP   Huang Gang G   Zhou Jiaxi J   Shi Lihong L   Xiao Zhijian Z  

Blood cancer journal 20200814 8


The underlying mechanisms and clinical significance of ineffective erythropoiesis in myelodysplastic syndromes (MDS) remain to be fully defined. We conducted the ex vivo erythroid differentiation of megakaryocytic-erythroid progenitors (MEPs) from MDS patients and discovered that patient-derived erythroblasts exhibit precocity and premature aging phenotypes, partially by inducing the pro-aging genes, like ERCC1. Absolute reticulocyte count (ARC) was chosen as a biomarker to evaluate the severity  ...[more]

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