Ontology highlight
ABSTRACT:
SUBMITTER: Huang H
PROVIDER: S-EPMC7429953 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Huang Huijun H Xu Changlu C Gao Jie J Li Bing B Qin Tiejun T Xu Zefeng Z Ren Sirui S Zhang Yudi Y Jiao Meng M Qu Shiqiang S Pan Lijuan L Hu Naibo N Liu Jinqin J Cai Wenyu W Zhang Yingnan Y Wu Dan D Zhang Peihong P Gale Robert Peter RP Huang Gang G Zhou Jiaxi J Shi Lihong L Xiao Zhijian Z
Blood cancer journal 20200814 8
The underlying mechanisms and clinical significance of ineffective erythropoiesis in myelodysplastic syndromes (MDS) remain to be fully defined. We conducted the ex vivo erythroid differentiation of megakaryocytic-erythroid progenitors (MEPs) from MDS patients and discovered that patient-derived erythroblasts exhibit precocity and premature aging phenotypes, partially by inducing the pro-aging genes, like ERCC1. Absolute reticulocyte count (ARC) was chosen as a biomarker to evaluate the severity ...[more]