Does activation of the protective Renin-Angiotensin System have therapeutic potential in COVID-19?
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ABSTRACT:
SUBMITTER: Namsolleck P
PROVIDER: S-EPMC7430134 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
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Does activation of the protective Renin-Angiotensin System have therapeutic potential in COVID-19?
Namsolleck Pawel P Moll Gert N GN
Molecular medicine (Cambridge, Mass.) 20200817 1
Infection of lung cells by the corona virus results in a loss of the balance between, on the one hand, angiotensin II-mediated stimulation of the angiotensin II type 1 receptor and, on the other hand, stimulation of the angiotensin II type 2 receptor and/or the Mas receptor. The unbalanced enhanced stimulation of the angiotensin II type 1 receptor causes inflammation, edema and contributes to the pathogenesis of severe acute respiratory distress syndrome. Here we hypothesize that stable, recepto ...[more]
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