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Renin-angiotensin system blockers and severe acute respiratory syndrome coronavirus 2.

ABSTRACT: Severe acute respiratory syndrome coronavirus 2, which is responsible for the current coronavirus disease 2019 pandemic, uses angiotensin-converting enzyme 2 as a gateway into host cells. In this review, we summarise the biology of this enzyme, which plays a key role in cardiovascular homeostasis. Blockers of the renin-angiotensin system modify the expression and activity of angiotensin-converting enzyme 2 in different ways. The effects of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on the expression and enzyme activity of angiotensin-converting enzyme 2 are reviewed, and the consequences of these treatments for the severity of coronavirus disease 2019 infection are discussed.

SUBMITTER: Levy BI

PROVIDER: S-EPMC7430243 | biostudies-literature | 2020 Aug - Sep

REPOSITORIES: biostudies-literature

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Renin-angiotensin system blockers and severe acute respiratory syndrome coronavirus 2.

Lévy Bernard I BI Fauvel Jean-Pierre JP

Archives of cardiovascular diseases 20200817 8-9

Severe acute respiratory syndrome coronavirus 2, which is responsible for the current coronavirus disease 2019 pandemic, uses angiotensin-converting enzyme 2 as a gateway into host cells. In this review, we summarise the biology of this enzyme, which plays a key role in cardiovascular homeostasis. Blockers of the renin-angiotensin system modify the expression and activity of angiotensin-converting enzyme 2 in different ways. The effects of angiotensin-converting enzyme inhibitors and angiotensin ...[more]

PMID: 32863157

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