Effects of renin-angiotensin system blockers on the risk and outcomes of severe acute respiratory syndrome coronavirus 2 infection in patients with hypertension.

ABSTRACT:

Background/aims

There are concerns that the use of renin-angiotensin system (RAS) blockers may increase the risk of being infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or progressing to a severe clinical course after infection. This this study aimed to investigate the influence of RAS blockers on the risk and severity of SARS-CoV-2 infection.

Methods

We conducted a retrospective cohort study analyzing nationwide claims data of 215,184 adults who underwent SARS-CoV-2 tests in South Korea. The SARS-CoV-2 positive rates and clinical outcomes were evaluated according to the use of RAS blockers in patients with hypertension (n = 64,243).

Results

In total, 38,919 patients with hypertension were on RAS blockers. The SARS-CoV-2 positive rates were

SUBMITTER: Lee J 

PROVIDER: S-EPMC8009159 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature