Ontology highlight
ABSTRACT:
SUBMITTER: Oguntuyo KY
PROVIDER: S-EPMC7430570 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Stevens Christian S CS Oguntuyo Kasopefoluwa Y KY Oguntuyo Kasopefoluwa Y KY Kowdle Shreyas S Kowdle Shreyas S Brambilla Luca L Brambilla Luca L Haas Griffin G Gowlikar Aditya A Siddiquey Mohammed Na MN Schilke Robert M RM Woolard Matthew D MD Zhang Hongbo H Acklin Joshua A JA Ikegame Satoshi S Huang Chuan-Tien CT Lim Jean K JK Cross Robert W RW Geisbert Thomas W TW Ivanov Stanimir S SS Kamil Jeremy P JP Lee Benhur B
bioRxiv : the preprint server for biology 20230508
<h4>Rationale</h4>SARS-CoV-2 entry into host cells is facilitated by endogenous and exogenous proteases that proteolytically activate the spike glycoprotein and antiproteases inhibiting this process. Understanding the key actors in viral entry is crucial for advancing knowledge of virus tropism, pathogenesis, and potential therapeutic targets.<h4>Objectives</h4>We aimed to investigate the role of naïve serum and alpha-1-antitrypsin (AAT) in inhibiting protease-mediated SARS-CoV-2 entry and explo ...[more]