Ontology highlight
ABSTRACT:
SUBMITTER: de Loyola MB
PROVIDER: S-EPMC7461031 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
de Loyola Mariana Braccialli MB Dos Reis Thaís Tereza Aguiar TTA de Oliveira Guilherme Xavier Lyra Malcher GXLM da Fonseca Palmeira Julys J Argañaraz Gustavo A GA Argañaraz Enrique R ER
Reviews in medical virology 20200826 2
Understanding Covid-19 pathophysiology is crucial for a better understanding of the disease and development of more effective treatments. Alpha-1-antitrypsin (A1AT) is a constitutive tissue protector with antiviral and anti-inflammatory properties. A1AT inhibits SARS-CoV-2 infection and two of the most important proteases in the pathophysiology of Covid-19: the transmembrane serine protease 2 (TMPRSS2) and the disintegrin and metalloproteinase 17 (ADAM17). It also inhibits the activity of inflam ...[more]