Ontology highlight
ABSTRACT:
SUBMITTER: Tauber M
PROVIDER: S-EPMC7430637 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Tauber Maria M Kreuz Sarah S Lemak Alexander A Mandal Papita P Yerkesh Zhadyra Z Veluchamy Alaguraj A Al-Gashgari Bothayna B Aljahani Abrar A Cortés-Medina Lorena V LV Azhibek Dulat D Fan Lixin L Ong Michelle S MS Duan Shili S Houliston Scott S Arrowsmith Cheryl H CH Fischle Wolfgang W
Nucleic acids research 20200801 14
UHRF1 is an important epigenetic regulator associated with apoptosis and tumour development. It is a multidomain protein that integrates readout of different histone modification states and DNA methylation with enzymatic histone ubiquitylation activity. Emerging evidence indicates that the chromatin-binding and enzymatic modules of UHRF1 do not act in isolation but interplay in a coordinated and regulated manner. Here, we compared two splicing variants (V1, V2) of murine UHRF1 (mUHRF1) with huma ...[more]