Ontology highlight
ABSTRACT:
SUBMITTER: Zhang ZM
PROVIDER: S-EPMC4558366 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Zhang Zhi-Min ZM Rothbart Scott B SB Allison David F DF Cai Qian Q Harrison Joseph S JS Li Lin L Wang Yinsheng Y Strahl Brian D BD Wang Gang Greg GG Song Jikui J
Cell reports 20150820 9
The protein stability and chromatin functions of UHRF1 (ubiquitin-like, containing PHD and RING finger domains, 1) are regulated in a cell-cycle-dependent manner. We report a structural characterization of the complex between UHRF1 and the deubiquitinase USP7. The first two UBL domains of USP7 bind to the polybasic region (PBR) of UHRF1, and this interaction is required for the USP7-mediated deubiquitination of UHRF1. Importantly, we find that the USP7-binding site of the UHRF1 PBR overlaps with ...[more]