Type I and type II Fc receptors regulate innate and adaptive immunity.
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ABSTRACT:
SUBMITTER: Pincetic A
PROVIDER: S-EPMC7430760 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Publications
Type I and type II Fc receptors regulate innate and adaptive immunity.
Pincetic Andrew A Bournazos Stylianos S DiLillo David J DJ Maamary Jad J Wang Taia T TT Dahan Rony R Fiebiger Benjamin-Maximillian BM Ravetch Jeffrey V JV
Nature immunology 20140801 8
Antibodies produced in response to a foreign antigen are characterized by polyclonality, not only in the diverse epitopes to which their variable domains bind but also in the various effector molecules to which their constant regions (Fc domains) engage. Thus, the antibody's Fc domain mediates diverse effector activities by engaging two distinct classes of Fc receptors (type I and type II) on the basis of the two dominant conformational states that the Fc domain may adopt. These conformational s ...[more]
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