Ontology highlight
ABSTRACT:
SUBMITTER: Cosma GL
PROVIDER: S-EPMC7430976 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Cosma Gabriela L GL Lobby Jenna L JL Fay Elizabeth J EJ Siciliano Nicholas A NA Langlois Ryan A RA Eisenlohr Laurence C LC
Proceedings of the National Academy of Sciences of the United States of America 20200727 32
The source proteins from which CD8<sup>+</sup> T cell-activating peptides are derived remain enigmatic. Glycoproteins are particularly challenging in this regard owing to several potential trafficking routes within the cell. By engineering a glycoprotein-derived epitope to contain an N-linked glycosylation site, we determined that optimal CD8<sup>+</sup> T cell expansion and function were induced by the peptides that are rapidly produced from the exceedingly minor fraction of protein mislocalize ...[more]