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The In Vitro Effect of Prostaglandin E2 and F2? on the Chemerin System in the Porcine Endometrium during Gestation.


ABSTRACT: Chemerin belongs to the group of adipocyte-derived hormones known as adipokines, which are responsible mainly for the control of energy homeostasis. Adipokine exerts its influence through three receptors: Chemokine-like receptor 1 (CMKLR1), G protein-coupled receptor 1 (GPR1), and C-C motif chemokine receptor-like 2 (CCRL2). A growing body of evidence indicates that chemerin participates in the regulation of the female reproductive system. According to the literature, the expression of chemerin and its receptors in reproductive structures depends on the local hormonal milieu. The aim of this study was to investigate the in vitro effect of prostaglandins E2 (PGE2) and F2? (PGF2?) on chemerin and chemerin receptor (chemerin system) mRNAs (qPCR) and proteins (ELISA, Western blotting) in endometrial tissue explants collected from early-pregnant gilts. Both PGE2 and PGF2? significantly influenced the expression of the chemerin gene, hormone secretion, and the expression of chemerin receptor genes and proteins. The influence of both prostaglandins on the expression of the chemerin system varied between different stages of gestation. This is the first study to describe the modulatory effect of PGE2 and PGF2? on the expression of the chemerin system in the porcine uterus during early gestation.

SUBMITTER: Dobrzyn K 

PROVIDER: S-EPMC7432131 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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The In Vitro Effect of Prostaglandin E<sub>2</sub> and F<sub>2α</sub> on the Chemerin System in the Porcine Endometrium during Gestation.

Dobrzyn Kamil K   Kiezun Marta M   Zaobidna Ewa E   Kisielewska Katarzyna K   Rytelewska Edyta E   Gudelska Marlena M   Kopij Grzegorz G   Bors Kinga K   Szymanska Karolina K   Kaminska Barbara B   Kaminski Tadeusz T   Smolinska Nina N  

International journal of molecular sciences 20200723 15


Chemerin belongs to the group of adipocyte-derived hormones known as adipokines, which are responsible mainly for the control of energy homeostasis. Adipokine exerts its influence through three receptors: Chemokine-like receptor 1 (CMKLR1), G protein-coupled receptor 1 (GPR1), and C-C motif chemokine receptor-like 2 (CCRL2). A growing body of evidence indicates that chemerin participates in the regulation of the female reproductive system. According to the literature, the expression of chemerin  ...[more]

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