Ontology highlight
ABSTRACT:
SUBMITTER: Kreitman RJ
PROVIDER: S-EPMC7433026 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Kreitman Robert J RJ Fitzgerald David J P DJ Pastan Ira I
Leukemia & lymphoma 20091001
The current hairy cell leukemia (HCL) treatment is excellent, but evidence of cure with purine analogs cladribine and pentostatin, is lacking. Significant long-term immune suppression, particularly to CD4+ T-cells, and declining complete remission rates with each course, make the identification of new therapies an important goal. The anti-CD20 monoclonal antibody (Mab) rituximab displays significant activity, and, while causing prolonged normal B-cell depletion, spares T-cells. Recombinant immun ...[more]