Ontology highlight
ABSTRACT:
SUBMITTER: Mack MR
PROVIDER: S-EPMC7433875 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Science translational medicine 20200201 532
Atopic dermatitis (AD) is a widespread, chronic skin disease associated with aberrant allergic inflammation. Current treatments involve either broad or targeted immunosuppression strategies. However, enhancing the immune system to control disease remains untested. We demonstrate that patients with AD harbor a blood natural killer (NK) cell deficiency that both has diagnostic value and improves with therapy. Multidimensional protein and RNA profiling revealed subset-level changes associated with ...[more]