Ontology highlight
ABSTRACT:
SUBMITTER: Tan JH
PROVIDER: S-EPMC7434440 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Tan June H JH Lautens Margot M Romanelli-Cedrez Laura L Wang Jianbin J Schertzberg Michael R MR Reinl Samantha R SR Davis Richard E RE Shepherd Jennifer N JN Fraser Andrew G AG Salinas Gustavo G
eLife 20200803
Parasitic helminths use two benzoquinones as electron carriers in the electron transport chain. In normoxia, they use ubiquinone (UQ), but in anaerobic conditions inside the host, they require rhodoquinone (RQ) and greatly increase RQ levels. We previously showed the switch from UQ to RQ synthesis is driven by a change of substrates by the polyprenyltransferase COQ-2 (Del Borrello et al., 2019; Roberts Buceta et al., 2019); however, the mechanism of substrate selection is not known. Here, we sho ...[more]