Ontology highlight
ABSTRACT:
SUBMITTER: Wilhelmi I
PROVIDER: S-EPMC4980449 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Wilhelmi Ilka I Kanski Regina R Neumann Alexander A Herdt Olga O Hoff Florian F Jacob Ralf R Preußner Marco M Heyd Florian F
Nature communications 20160805
The transport of secretory proteins from the endoplasmic reticulum (ER) to the Golgi depends on COPII-coated vesicles. While the basic principles of the COPII machinery have been identified, it remains largely unknown how COPII transport is regulated to accommodate tissue- or activation-specific differences in cargo load and identity. Here we show that activation-induced alternative splicing of Sec16 controls adaptation of COPII transport to increased secretory cargo upon T-cell activation. Usin ...[more]