Ontology highlight
ABSTRACT:
SUBMITTER: Siraj AK
PROVIDER: S-EPMC7434734 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Siraj Abdul K AK Bu Rong R Iqbal Kaleem K Parvathareddy Sandeep K SK Masoodi Tariq T Siraj Nabil N Al-Rasheed Maha M Kong Yan Y Ahmed Saeeda O SO Al-Obaisi Khadija A S KAS Victoria Ingrid G IG Arshad Maham M Al-Dayel Fouad F Abduljabbar Alaa A Ashari Luai H LH Al-Kuraya Khawla S KS
Molecular genetics & genomic medicine 20200622 8
<h4>Background</h4>Colorectal cancer (CRC) is a major contributor to morbidity and mortality related to cancer. Only ~5% of all CRCs occur as a result of pathogenic variants in well-defined CRC predisposing genes. The frequency and effect of exonuclease domain pathogenic variants of POLE and POLD1 genes in Middle Eastern CRCs is still unknown.<h4>Methods</h4>Targeted capture sequencing and Sanger sequencing technologies were employed to investigate the germline exonuclease domain pathogenic vari ...[more]