Dataset Information

Reduced levels of circulating adhesion molecules in adolescents with early-onset psychosis.

ABSTRACT: It is suggested that neurodevelopmental abnormalities are involved in the disease mechanisms of psychotic disorders. Although cellular adhesion molecules (CAMs) participate in neurodevelopment, modulate blood-brain barrier permeability, and facilitate leukocyte migration, findings concerning their systemic levels in adults with psychosis are inconsistent. We examined plasma levels and mRNA expression in peripheral blood mononuclear cells (PBMCs) of selected CAMs in adolescents with early-onset psychosis (EOP) aged 12-18 years (n?=?37) and age-matched healthy controls (HC) (n?=?68). EOP patients exhibited significantly lower circulating levels of soluble platelet selectin (~-22%) and soluble vascular cell adhesion molecule-1 (~-14%) than HC. We found no significant associations with symptom severity. PSEL mRNA expression was increased in PBMCs of patients and significantly negatively correlated to duration of illness. These findings suggest a role for CAMs in the pathophysiology of psychotic disorders.

SUBMITTER: Wedervang-Resell K

PROVIDER: S-EPMC7434772 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Reduced levels of circulating adhesion molecules in adolescents with early-onset psychosis.

Wedervang-Resell Kirsten K Ueland Thor T Aukrust Pål P Friis Svein S Holven Kirsten B KB H Johannessen Cecilie C Lekva Tove T Lonning Vera V Smelror Runar E RE Szabo Attila A Andreassen Ole A OA Myhre Anne M AM Agartz Ingrid I

NPJ schizophrenia 20200818 1

It is suggested that neurodevelopmental abnormalities are involved in the disease mechanisms of psychotic disorders. Although cellular adhesion molecules (CAMs) participate in neurodevelopment, modulate blood-brain barrier permeability, and facilitate leukocyte migration, findings concerning their systemic levels in adults with psychosis are inconsistent. We examined plasma levels and mRNA expression in peripheral blood mononuclear cells (PBMCs) of selected CAMs in adolescents with early-onset p ...[more]

PMID: 32811840

Dataset Information

Reduced levels of circulating adhesion molecules in adolescents with early-onset psychosis.

Publications

Reduced levels of circulating adhesion molecules in adolescents with early-onset psychosis.

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